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Reputable Mentor II
Reputable Mentor II


May 24, 2010 New products deliver next-level integration, simplicity, productivity and performance to speed progress in life science research. Thermo Fisher Scientific Inc., the world leader in serving science, today announced important enhancements for its proteomics tools that promise to facilitate breakthrough progress in quantitative and qualitative proteomics. The new products work in concert with other Thermo Fisher Scientific products including reagents and consumables to create simpler, time-saving workflows. These solutions will be displayed at the Salt Palace Convention Center Salons 250BCEF, May 24 – May 26, 2010 during the ASMS Conference on Mass Spectrometry and Allied Topics in Salt Lake City, Utah. “Breakthrough discoveries in biology and progress in biomarker research have been made possible in large part by new technologies. The Thermo Scientific brand is a leader in such innovative technologies, and provides a full line of products that integrate seamlessly into solutions. These include mass spectrometry and liquid chromatography systems, software, and sample preparation reagents and kits,” said Andreas Huhmer, proteomics marketing director for life sciences mass spectrometry at Thermo Fisher Scientific. “The products we showcase at ASMS strengthen our ability to provide researchers with end-to-end solutions that reduce complexity and increase the speed of, and information derived from, proteomics workflows.” Pinpoint software enhances productivity and confidence in results Thermo Scientific Pinpoint software simplifies the transition from early-stage biomarker discovery to larger-scale, quantitative verification of putative biomarkers. It allows researchers to leverage previously acquired discovery data from mass spectrometers such as the Thermo Scientific LTQ Velos and LTQ Orbitrap Velos to speed and simplify development of quantitative assays using intelligent SRM (iSRM). One of the biggest challenges in quantitative proteomics is to simultaneously verify and quantify low-level biomarkers reproducibly from run-to-run. iSRM, available on all Thermo Scientific TSQ triple-stage quadrupole instruments, increases the sensitivity, selectivity, and throughput of targeted quantitation assays allowing the simultaneous verification and quantification of thousands of targeted peptides in a single run. A prototype version of Pinpoint software was distributed to over 300 proteomics researchers worldwide who used it to increase productivity and further proteomics research. Thermo Fisher Scientific incorporated their feedback into a commercially available version, with enhancements that are designed to optimize productivity, data quality and confidence in results. The software now processes a large number of data files, enables researchers to incorporate information from global protein and peptide spectral databases, and has been enhanced to facilitate analysis of phosphopeptides and glycopeptides. Proteome Discoverer software enhances productivity and quantitative results Thermo Scientific Proteome Discoverer software is a comprehensive platform for the analysis of quantitative and qualitative proteomics data. It addresses the need for flexibility by offering a wide array of bio-software tools and customizable workflows for every imaginable proteomics experiment. Proteome Discoverer software has new capabilities that boost productivity and improve quantitative results. It now supports a wide range of stable isotope labeling with amino acids in cell culture (SILAC) experiments to speed quantitation of protein expression levels from differentially treated cell populations. SILAC experiments that were once very tedious are now remarkably easy. It also offers enhanced capabilities for relative quantitation using isobaric mass tags, such as Thermo Scientific Mass Tags (TMT), with statistical analysis of results. Flexible handling of peptide identification improves coverage and relative quantitation, and data processing following data collection can now be automated.



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