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Quantitation of Seven Designer Cathinones in Urine Using Q Exactive Mass Spectrometer

Reputable Mentor II
Reputable Mentor II
Kozak M, Van Natta K, Sheng S
Purpose: To develop an HPLC-MS method for the forensic toxicological analysis of the three Schedule I cathinones: MDPV, methylone and mephedrone, as well as other substituted cathinones: methedrone, ethylone, butylone and naphyrone in urine with limits of quantitation (LOQs) of 0.5 ng/mL. Methods: Liquid/liquid extraction followed by HPLC/MS/MS analysis on a Thermo Scientific™ Q Exactive™ benchtop Orbitrap mass spectrometer. Results: We achieved LOQs of 0.5 ng/mL with good reproducibility and accuracy for MDPV, mephedrone, methylone, methylone, ethylone and butylone. Naphyrone showed more variability and is considered qualitative using this method.

Thermo Fisher Scientific
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Last update:
‎10-15-2021 08:36 AM
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