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Quantitation of Immunosuppressant Drugs in Blood Utilizing Second Generation Exactive High Resolution Accurate Mass Spectrometer and TraceFinder Software

Reputable Mentor II
Reputable Mentor II
Van Natta K, Kozak M, Nimkar S, Clarke W.
ASMS 2012 Poster
Purpose: Evaluate second generation Thermo Scientific Exactive™ high performance bench-top mass spectrometer for analysis of immunosuppressant drugs in whole blood for clinical research use only utilizing the Thermo Scientific ClinSpec Immunosuppressant Test kit and samples previously analyzed by a clinically validated method on a triple stage quadrupole mass spectrometer. Methods: Whole blood samples were processed by precipitation with ZnSO4/ methanol. Samples were injected onto an HPLC under gradient conditions and detected on an Exactive Plus mass spectrometer. Results: Standards and controls from test kit passed all method parameters for linearity recovery. This method showed excellent correlation with a clinically validated triple stage quadrupole method.

Thermo Fisher Scientific
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Last update:
‎10-15-2021 09:42 AM
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