Quantifying Peptides in Complex Mixtures with High Sensitivity and Precision Using a Targeted Approach with a Hybrid Linear Ion Trap-Orbitrap Mass Spectrometer

[Orbitrap_SciLib]

Kiyonami R, Zeller M, Zabrouskov V.
Application Note 557
For targeted HR/AM quantitation, hybrid ion trap-Orbitrap mass spectrometers offer the same detection advantages as they do for the data-dependent peptide discovery. The Orbitrap mass analyzer provides high mass accuracy, high intra-scan dynamic range, low detection limits as ions of a specific m/z can be accumulated/enriched in the mass spectrometer prior to detection, and ultra-high resolution. Simultaneously, the linear ion trap provides high sensitivity and fast cycle time.


Thermo Fisher Scientific