The Thermo Scientific Q Exactive UHMR hybrid Quadrupole-Orbitrap mass spectrometer combines in-source trapping, high performance quadrupole precursor ion selection, a higher-energy collisional dissociation (HCD) cell, and a high-resolution, accurate-mass (HRAM) Orbitrap mass analyzer, with optimized RF voltages for improved high mass ion transmission to provide unrivaled sensitivity and resolution in the ultra-high mass range.