Showing results for 
Search instead for 
Did you mean: 

Pre-filtering ions in the source region to improve instrument robustness and dynamic range

Reputable Mentor II
Reputable Mentor II
McAlister G, Senko S.
ASMS 2015 Poster
Purpose: To implement a low-pass ion filter in the source region of a Thermo Scientific™ OrbitrapFusion Lumos™ Tribrid™ mass spectrometer. Methods: We modified the existing electronics to supply a resolving DC to the ion guide in the source region, and we tested a series of ion guide assemblies. Results: We improved the resolution of the source filter 2-fold by exchanging the standard flat rod ion guide for an ion guide with round rods and a smaller inscribed radius. With this optimal ion guide, we can remove 40% of the unwanted ions during a typical shotgun proteomics LC-MS/MS analysis.

Thermo Fisher Scientific
Version history
Last update:
‎10-15-2021 11:35 AM
Updated by: