Damoc E, Yip P, Valmu L, Cherkassky A, Delanghe B, Denisov E, Cardasis H, Neil J, Makarov A, Stephenson J.
ASMS 2015 Poster Note 64455
Purpose: Evaluation of the Thermo Scientific™ Q Exactive™ HF hybrid quadrupole-Orbitrap mass spectrometer for high-throughput top-down proteomics.
Methods: Top-down analysis of an Escherichia coli extract using the data dependent “TopN” method with and without chromatographic separation.
Results: We demonstrate utility and applicability of the Q Exactive HF mass spectrometer to perform high-throughput top-down proteome analysis.
Thermo Fisher Scientific
United States
