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Overcoming the challenges in Data Independent Acquisition (DIA) via high resolution accurate mass Orbitrap based mass spectrometer

Reputable Mentor II
Reputable Mentor II
Xuan Y, Muntel J, Berger S, Huhmer A, Steen H, Moehring T.
ASMS 2015 Poster
Purpose: Utilize Thermo Scientific Q Exactive HF mass spectrometer for DIA LC-MS/MS experiments to study the urinary proteome, and demonstrate how high resolution/accurate mass spectrometry is employed to overcome DIA challenges and enable large scope of urine proteomics studies. Results: In this study, we have developed a robust DIA method for the comprehensive mapping of the urinary proteome that enables large scale urine proteomics studies with high throughput ( less than 4 days for 87 biological sample measurements) and excellent reproducibility (media of CV% is 7%).

Thermo Fisher Scientific and Boston Children's Hospital
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Last update:
‎10-15-2021 11:34 AM
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