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Orbitrap Mass Spectrometry With Resolving Powers Above 500,000 and 1,000,000 on a Chromatographic Time Scale

Reputable Mentor II
Reputable Mentor II
Denisov E, Damoc E, Makarov A, Lange O.
ASMS 2011 Poster
Typically, an Orbitrap mass spectrometer is expected to provide resolving power of not higher than 100,000-200,000 which corresponds to detection time of 1-2 seconds. Recent innovations in Orbitrap technology, such as the high-field Orbitrap mass analyzer and advanced signal processing method, allowed us to accelerate detection by around 3.6-fold. This allows not only an accelerated spectral acquisition rate but makes it possible to do the opposite: to use longer transients to achieve higher resolving power while still remaining on time scale compatible with chromatographic separations.

Thermo Fisher Scientific, Bremen, Germany
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Last update:
‎10-15-2021 06:25 AM
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