Orbitrap Mass Spectrometry With Resolving Powers Above 500,000 and 1,000,000 on a Chromatographic Time Scale

[Orbitrap_SciLib]

Denisov E, Damoc E, Makarov A, Lange O.
ASMS 2011 Poster
Typically, an Orbitrap mass spectrometer is expected to provide resolving power of not higher than 100,000-200,000 which corresponds to detection time of 1-2 seconds. Recent innovations in Orbitrap technology, such as the high-field Orbitrap mass analyzer and advanced signal processing method, allowed us to accelerate detection by around 3.6-fold. This allows not only an accelerated spectral acquisition rate but makes it possible to do the opposite: to use longer transients to achieve higher resolving power while still remaining on time scale compatible with chromatographic separations.


Thermo Fisher Scientific, Bremen, Germany