Botanicals contain a great diversity of compounds that exhibit wide variation in their
physicochemical properties. Although no single analytical method is available to
measure all potentially active components, HPLC with charged aerosol detection
Is a nearly universal approach that
nonselectively
measures any nonvolatile and
many
semivolatile
compounds; that is, charged aerosol detection does not require
that analytes be
ionizable
(as required for mass spectrometry) or contain a
chromophore (as required for UV
spectrophotometr
United States
