So, what does high resolution, accurate mass, full-scan mass spectrometry bring to the gas chromatography party? Hans Mol, Jana Hajšlová, Richard Fussell, and Amadeo Fernández-Alba consider the value of such technology – especially with the launch of the new Thermo Scientific™ Exactive™ GC system, which brings the power of Orbitrap GC-MS into the routine environment. And Joshua Coon, Nicholas Kwiecien, and Karl Burgess reflect on the implications for the highly complex world of metabolomics, where advanced tools that can increase metabolite coverage are always highly anticipated. Welcome to “Next Generation GC-MS.”