Showing results for 
Search instead for 
Did you mean: 
Reputable Mentor II
Reputable Mentor II
Martins TM, Núñez O, Gallart-Ayala H, Leitão MC, Galceran MT, Silva Pereira C.
J Hazard Mater. 2014 Mar 15;268:264-72. doi: 10.1016/j.jhazmat.2014.01.024. Epub 2014 Jan 25.
A collective view of the degradation of monochlorocatechols in fungi is yet to be attained, though these compounds are recognised as key degradation intermediates of numerous chlorinated aromatic hydrocarbons, including monochlorophenols. In the present contribution we have analysed the degradation pathways of monochlorophenols in Aspergillus nidulans using essentially metabolomics. Degradation intermediates herein identified included those commonly reported (e.g. 3-chloro-cis,cis-muconate) but also compounds never reported before in fungi revealing for 4-chlorocatechol and for 3-chlorocatechol unknown degradation paths yielding 3-chlorodienelactone and catechol, respectively. A different 3-chlorocatechol degradation path led to accumulation of 2-chloromuconates (a potential dead-end), notwithstanding preliminary evidence of chloromuconolactones and protoanemonin simultaneous formation. In addition, some transformation intermediates, of which sulfate conjugates of mono-chlorophenols/chlorocatechols were the most common, were also identified. This study provides critical information for understanding the role of fungi in the degradation of chlorinated aromatic hydrocarbons; furthering their utility in the development of innovative bioremediation strategies.
Universidade Nova de Lisboa, University of Barcelona
Version history
Last update:
‎10-15-2021 05:01 AM
Updated by: