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Reputable Mentor II
Reputable Mentor II
Burns KE, McAllister F, Schwerdtfeger C, Mintseris J, Cerda-Maira F, Noens EE, Wilmanns M, Hubbard SR, Melandri F, Ovaa H, Gygi SP, Darwin KH.
J Biol Chem. 2012 Oct 26;287(44):37522-9.
Dop, the Pup deconjugating enzyme, is critical for the full virulence of Mycobacterium tuberculosis and is unique to bacteria, providing an ideal target for the development of selective chemotherapies. We used a combination of genetics and chemical biology to characterize the mechanism of depupylation. We identified an aspartate nucleophile in the active site of Dop, suggesting a novel protease activity to target for inhibitor development.
New York University School of Medicine, United States.
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