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Reputable Mentor II
Reputable Mentor II
Egertson JD, Kuehn A, Merrihew GE, Bateman NW, Maclean BX, Ting YS, Canterbury JD, Marsh DM, Kellmann M, Zabrouskov V, Wu CC, Maccoss MJ.
Nat Methods. 2013 Jun 23.
In mass spectrometry-based proteomics, data-independent acquisition (DIA) strategies can acquire a single data set useful for both identification and quantification of detectable peptides in a complex mixture. However, DIA data are noisy owing to a typical five- to tenfold reduction in precursor selectivity compared to data obtained with data-dependent acquisition or selected reaction monitoring. We demonstrate a multiplexing strategy, MSX, for DIA analysis that increases precursor selectivity fivefold.

http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.2528.html
Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
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