on 08-15-201206:46 AM - edited on 11-09-202101:41 AM by usermigration2
Sanders M, Hnatyshyn S, Robertson D, Reily M, McClure T, Athanas M, Wang J, Yang P, Huang H, Peake D. Application Note 562 Metabolomics is used within the pharmaceutical industry to investigate biochemical changes resulting from pharmacological responses to potential drug candidates. The ability to identify markers of toxicity/efficacy can significantly accelerate drug discovery and help define the appropriate clinical plan. Data from liquid chromatography-mass spectrometry (LC-MS) metabolomic profiling experiments
contains large amounts of chemical background that often confounds biomarker discovery. New mass spectrometer technology and data processing software were utilized here to reduce chemical background in animal experiments investigating the relation of animal age and nutrition to discerning drug-induced changes.