Metabolomic Profiling in Drug Discovery: Understanding the Factors that Influence a Metabolomics Study and Strategies to Reduce Biochemical and Chemical Noise

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Sanders M, Hnatyshyn S, Robertson D, Reily M, McClure T, Athanas M, Wang J, Yang P, Huang H, Peake D.
Application Note 562
Metabolomics is used within the pharmaceutical industry to investigate biochemical changes resulting from pharmacological responses to potential drug candidates. The ability to identify markers of toxicity/efficacy can significantly accelerate drug discovery and help define the appropriate clinical plan. Data from liquid chromatography-mass spectrometry (LC-MS) metabolomic profiling experiments contains large amounts of chemical background that often confounds biomarker discovery. New mass spectrometer technology and data processing software were utilized here to reduce chemical background in animal experiments investigating the relation of animal age and nutrition to discerning drug-induced changes.


Thermo Fisher Scientific