Metabolomic Profiling in Drug Discovery: Understanding the factors that influence a metabolomics study and strategies to reduce biochemical and chemical noise

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Sanders M, Hnatyshyn S, Robertson D, Reily M, McClure T, Athanas M, Wang J, Yang P, Peake D.
ASMS 2011 Slide Presentation
Goals: • Quantitative assessment of the biochemical makeup of the samples • Differential analysis between sample groups • Identify compounds responsible for changes Challenges: • Complexity of a biological sample • Diversity of small molecule metabolites • Wide range of metabolite concentration • Multiple sources of variability • Incomplete information – majority of components seen by LC/MS are unknowns • Structure elucidation of unknowns is expensive


Thermo Fisher Scientific