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Metabolomic Profiling in Drug Discovery: Understanding the factors that influence a metabolomics study and strategies to reduce biochemical and chemical noise

Reputable Mentor II
Reputable Mentor II
Sanders M, Hnatyshyn S, Robertson D, Reily M, McClure T, Athanas M, Wang J, Yang P, Peake D.
ASMS 2011 Slide Presentation
Goals: • Quantitative assessment of the biochemical makeup of the samples • Differential analysis between sample groups • Identify compounds responsible for changes Challenges: • Complexity of a biological sample • Diversity of small molecule metabolites • Wide range of metabolite concentration • Multiple sources of variability • Incomplete information – majority of components seen by LC/MS are unknowns • Structure elucidation of unknowns is expensive

Thermo Fisher Scientific
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Last update:
‎10-15-2021 06:29 AM
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