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Orbitrap_SciLib
Reputable Mentor II
Reputable Mentor II
Stratton T, Ding C, Huang Y, Schaeffer D.
Application Note 564
Early screening of drug candidates for favorable in vitro metabolic stability can provide a window on potential pharmacokinetic performance and interspecies scaling and offer feedback to medicinal chemistry to improve upon compound series. Historically these screening assays used triple-stage quadrupole mass spectrometers, which provide good quantitative data but require compoundspecific tuning. Qualitative data was limited without significant additional method development. We present here the use of a benchtop high-resolution, accurate-mass mass spectrometer coupled with acquisition and processing software for simultaneous quantitative and qualitative (quan/qual) analysis of in vitro samples.


Thermo Fisher Scientific
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‎10-15-2021 11:17 AM
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