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Measuring Designer Drugs of Abuse

Reputable Mentor II
Reputable Mentor II
Wu A, Gerona R.
Designer amines such as mephedrone, 3,4 methylenedixypyrovalerone, and methylone are being sold for drug abuse purposes. They are marketed on the internet as "bath salts", a means to disguise the true intent of the products. Many of these compounds have been put on the controlled substances list by the US Drug Enforcement Agency and regulatory bodies from other countries. Synthetic cathinones are not detected by the current drug screening immunoassays in urine. Therefore, analysis requires use of mass spectrometry. As there are many different synthetic amines that are abused, it is difficult for an analytical laboratory to obtain standards for these drugs and their metabolites. High-resolution mass spectrometry enables detection of exact molecular formula and may be an effective screening assay to detect abuse of designer amines.
San Francisco General Hospital & Trauma Center and the Department of Laboratory Medicine, UCSF
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Last update:
‎11-09-2021 01:24 AM
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