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Maximizing Proteome Coverage with Advanced Peak Determination Algorithm on Tribrid Mass Spectrometers

Reputable Mentor II
Reputable Mentor II
Helene L. Cardasis1, Graeme C. McAlister1, Christian Thoeing2, Philip Remeš1, Andreas Kuehn2, Mike Senko1, Shannon Eliuk1, Romain Huguet1, Vlad Zabrouskov1.
ASMS 2018
Thermo Scientific™ Tribrid™ mass spectrometers are incredibly versatile instruments that combine multiple empowering MS technologies into a single platform. Working together, these technologies can sequence tens of thousands of peptides during a data-dependent LC-MS/MS analysis of a complex peptidic sample. To push sampling depths even further, we have deployed a peak determination algorithm that identifies hundreds of thousands of additional precursors. To better sample all these additional precursors, we configured the ion trap to collect MS2 spectra at up to 40 Hz. Together these changes allow us to collect hundreds of thousands of MS2 spectra, which translates into >35% more unique peptide identifications.

1 Thermo Fisher Scientific, San Jose, CA 2 Thermo Fisher Scientific, Bremen, Germany
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Last update:
‎10-15-2021 11:31 AM
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