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Orbitrap_SciLib
Reputable Mentor II
Reputable Mentor II
Scott Peterman1, Romain Huguet1, Michael Belford1, Susan Abbatiello2
ASMS 2019 Poster
Purpose: Increase the plasma proteome coverage for routine profiling analysis. Methods: Incorporation of the Thermo Scientific™ FAIMS Pro™ interface with the Thermo Scientific™ Orbitrap™ Tribrid™ mass spectrometer to expand the precursor features reproducibly measured and sequenced. The proposed FAIMS DDA method utilizes two CV settings. Results: Introduction of the FAIMS Pro interface into the DDA method resulted in detection and quantitation of ca. 1200 additional peptides and over 100 proteins. In addition, the FAIMS DDA experiment converted 33 proteins identified as “1-hit wonders” as defined in the standard DDA experiment to proteins quantified by 2 or more peptides.


1 Thermo Fisher Scientific, San Jose, CA, USA, 95134 2 Northeastern University, Boston, MA 02115
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Last update:
‎10-15-2021 11:30 AM
Updated by:
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