Originally appearing in Chemical & Engineering on April 3, 2006
Unveiled in June 2005, the LTQ Orbitrap is touted as "the first new mass analyzer to be introduced to the market in over 20 years." The instrument uses the Orbitrap, a type of Fourier transform mass analyzer that radially traps ions around a central spindle electrode, as the detector for ions produced in the LTQ linear ion trap mass spectrometer. The combined instruments, linked by an intermediate storage trap, provide for fast, sensitive, and reliable mass spectrometric and tandem MS analysis of compounds in complex mixtures for small-molecule research, drug discovery, and proteomics and metabolomics applications.