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Orbitrap_SciLib
Reputable Mentor II
Reputable Mentor II
Hao Z, Zhang Y, Horn D, Sharma S, Wu S, Lin I, Pan Y, Yang Y, Huhmer A.
ASMS 2012 Oral Presentation
Monoclonal antibodies (mAbs) are increasingly developed and utilized for the detection and treatment of diseases including cancer. Due to the heterogeneity of mAb products, thorough characterization is necessary for their reproducible as well as safe production. Among the analytical tools used for the analysis of therapeutic mAb, mass spectrometry (MS), especially high resolution and accurate mass MS, has become more and more important in providing accurate information on various protein properties, such as intact molecular mass, glycosylation form distribution, amino acid sequence, post-translational modifications, minor impurities due to sample processing and high order structure, etc. In this study, an orbitrap based LC-MS workflow solution was developed for robust, accurate and comprehensive mAb characterization at intact protein level.


Thermo Fisher Scientific
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