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Orbitrap_SciLib
Reputable Mentor II
Reputable Mentor II
Lin S, Hao Z, Decrop W, Baek J, Aich U, Bennett P, Rao S, Agroskin Y, Pohl C, Milton D
ASMS 2013 Poster Note
Purpose: Intact mass analysis of monoclonal antibody (MAb) charge variants separated using linear pH gradient. Methods: The separation of MAb charge variants is achieved using linear pH gradient method on a cation-exchange column. The intact mass information is acquired on the Thermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap mass spectrometer. Results: This linear pH gradient enables the high resolution separation of MAb charge variants. The intact mass analysis characterizes the structural difference of the MAb variants.


Thermo Fisher Scientific
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Last update:
‎10-15-2021 07:46 AM
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