on 05-01-201210:54 AM - edited on 10-15-202111:40 AM by AnalyteGuru
Zeller M, Crone C, Mueller M, Damoc E, Denisov E, Makarov A, Nolting D, Moehring T.
ASMS 2011 Poster One of the biggest challenges in shot-gun proteomics of complex samples remains undersampling. Besides the ion accumulation time to reach the target value in ion trap hybrid mass spectrometer, the detect time in the Orbitrap detector has the biggest portion in the overall scan process. Improvements resulting in higher resolution or in higher scan speed at the same resolution significantly decrease the overall cycle time. In this work we present the advances in analytical performance using modifications to hardware and software on an ion trap-hybrid MS based instrument platform.