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Orbitrap_SciLib
Reputable Mentor II
Reputable Mentor II
Abbatiello S, Cardasis H, Belford M, Sarracino D, Neil J, Stephenson J, Dunyach J, Blackburn M.
ASMS 2015 Poster Note 64473
Purpose: Evaluate FAIMS for the improved detection of proteins by infusion. Methods: Protein standards and samples (from cell lysates or digested plasma) were infused at 3 uL/min using FAIMS on a Thermo ScientificTM Orbitrap Velos ProTM mass spectrometer. Compensation voltages were stepped to promote separation of analytes from high-intensity singly charged contaminant and other sample-related background ions. Results: Detection of protein ions by infusion was drastically improved using FAIMS. Singly charged contaminant ions were preferentially excluded during mass detection, resulting in significantly improved signal-to-noise of over 50 proteins in a cell lysate. Detection of insulin was also improved versus no FAIMS, resulting in simplified, chromatography-free sample introduction.


Thermo Fisher Scientific
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‎10-15-2021 12:04 PM
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