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Identifying Quantitative Protein Changes in Iris Biopsies of Glaucoma Patients Using Label Free Proteomics

Reputable Mentor II
Reputable Mentor II
Craig Dufresne1, Richard Semba2, Pingbo Zhang2, Min Zhu2, Jiang Qian3, Tianshun Gao3, Ibrahim AlJadaan4, Sami AlShahwan4, Ohood Owaidha4, Randy Craven2, Deepak Edward2,4, Alka Mahale4;  

Purpose: Label free quantification (LFQ) of iris biopsies from patients with primary angle closure glaucoma (PACG) compared to healthy eyes. Methods: Quadrupole-Orbitrap mass spectrometry quantitative proteomics. Results: LFQ identified differences in protein concentrations between PACG and control iris samples, providing new insights into pathogenesis of glaucoma.

1Thermo Fisher Scientific, West Palm Beach, FL, United States; 2Johns Hopkins University, Baltimore, MD, United States; 3National Institute on Aging, National Institutes of Health, Baltimore, MD, United States; 4King Khaled Eye Specialist Hospital, Riyadh, Central, Saudi Arabia
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Last update:
‎10-15-2021 07:05 AM
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