Identification of T cell receptor signaling pathway proteins in a feline large granular lymphoma cell line by liquid chromatography tandem mass spectrometry.

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Henrich M, Huber K, Rydzewski L, Kirsten S, Spengler B, Römpp A, Reinacher M.
Vet Immunol Immunopathol. 2014 Sep 15;161(1-2):116-21. doi: 10.1016/j.vetimm.2014.06.004. Epub 2014 Jun 26.
Tryptic peptides of a feline large granular lymphoma cell line were analyzed by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Seventeen proteins of the T cell receptor signaling pathway could be identified by this approach. So far the existence of these proteins has only been postulated in the protein databases while experimental proof of their expression is predominantly pending. This article suggests where these proteins are located within the T cell receptor signaling pathway, thereby giving a short overview of the structure and function of this cascade.

http://www.sciencedirect.com/science/article/pii/S0165242714001445