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Hydrophilic Interaction Liquid Chromatography: Some Aspects of Solvent and Column Selectivity

Scientific Advocate II
Scientific Advocate II
The retention mechanisms of five stationary phases were investigated when using hydrophilic interaction liquid chromatography (HILIC) for the separation of small polar compounds. The effect on retention of changing acetonitrile content, column temperature and buffer concentration in the mobile phase was investigated. This study highlighted differences in retentivity and selectivity, which could assist during HILIC method development.
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Last update:
‎08-19-2015 04:33 AM
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