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Reputable Mentor II
Reputable Mentor II
Moulard Y, Bonnaire Y, Duretz B, Robinson S, Scurati S, Nagtalon D.
Scientific Poster
Liquid chromatography–mass spectrometry (LC-MS/MS) technology has revolutionized the types of detection assays used in doping control analysis over the last decade. Triple quadrupole or tandem mass spectrometers have been used most frequently in this area and provide accurate identification, confirmation, and quantification of prohibited compounds in a single analysis. In addition, ion trap and quadrupole time-of-flight mass spectrometers have been useful for screening and confirming results. However, these technologies cannot address all of the main requirements of doping control analysis such as: • Data re-interrogation • Unlimited number of compounds scanned during the analysis • Fast and easy method development • High resolution to efficiently separate analytes from interferences present in the matrix • High mass accuracy to identify compounds by exact mass Here we present a screening approach that uses high mass accuracy and high resolution (R = 50,000) in positive and negative polarities for the accurate screen Thermo Scientific Exactive mass spectrometer. More than 120 analytes are ing of illicit substances in urine matrix using the screened using this method. Unequivocal compound identification and confirmation are made using the exact mass of the analytes in positive and negative mode (if available) and the retention time.

Thermo Fisher Scientific
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Last update:
‎10-15-2021 11:21 AM
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