High-Resolution Separation of Cysteine-Conjugated Antibody Drug Mimics

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This application note demonstrates the analysis of antibody-drug conjugate
(ADC) mimics using a Thermo ScientificTM MAbPacTM HIC-10 column.
Cysteine-conjugated ADC mimics were successfully separated based on
the drug-to-antibody ratio (DAR). Separation of ADC mimics was optimized
by adjusting temperature, solvent content, and solvent gradient.