High Resolution LC-MS for Screening and Quantitative Analysis of Antibiotics in Drinking Water Using an Orbitrap and Online Sample Preparation

[Orbitrap_SciLib]

Beck J, Yang C, Ghosh D, Akervik K.
ASMS 2012 Poster
Purpose: To demonstrate online sample pre-concentration and extraction of water samples and analysis with high-resolution, accurate mass (HR/AM) detection, quantitation and confirmation. Methods: Inject 1 mL water samples directly onto a trapping column. The trapped compounds are then backflushed onto an analytical HPLC column and detected using a Thermo Scientific Orbitrap mass analyzer. Results: This poster describes a method to perform screening and quantitation of antibiotics at ppt and sub-ppt levels in drinking water using online pre-concentration together with HR/AM confirmations of the compounds.


Thermo Fisher Scientific