Until now, high resolution Orbitrap mass spectrometry has been available only with liquid chromatography and has proven to be a highly valuable analytical technique. Orbitrap mass spectrometry technology has now been coupled to gas chromatography (GC) in the Thermo Scientific™ Q Exactive™ GC hybrid quadrupole-Orbitrap mass spectrometer system. This novel configuration of a benchtop hybrid quadrupole-Orbitrap mass spectrometer opens up new possibilities for GC-amenable compounds.