In this study, we evaluate the performance of the Thermo Scientific™ Q Exactive™ GC hybrid quadrupole-Orbitrap mass spectrometer (MS) for the accurate screening of GC-amenable pesticides. The Q Exactive GC Orbitrap MS provides high mass resolving power up to 120,000 (m/z 200) full width half maxima (FWHM) to facilitate highly accurate mass measurements and to enable confident discrimination of co-eluting and isobaric compounds in complex samples. Fast scan speeds and a high intrascan dynamic range (>5000) facilitate the detection of trace compounds in the presence of high matrix components.