Many drugs are manufactured in a salt form to provide solubility, bioavailability, and stability. Counter ion determinations are important to confirm the correct stoichiometry and formula weight of the drug but also to test for drug impurities. High Pressure Capillary ion chromatography is the latest advancement in ion chromatography instrumentation. Typically with an Reagent-Free™ ion chromatography (RFIC™) system, the system pressure is limited to < 3000 psi because of the limitations of materials in the RFIC accessories. Now with the upgrade to high pressure, the Thermo Scientific™ Dionex™ ICS-5000+ HPIC™ capillary system can operate at system pressures < 5000 psi.