A liquid chromatography–tandem mass spectrometry method for the analysis of dextromethorphan and dextrorphan from rat plasma has been developed. A limit of quantification of 0.1 ng/mL is readily achieved. When using Thermo Scientific™ SOLA™ CX cartridges or plates, sample preparation is fast and reproducible giving excellent precision, low matrix suppression, and good recovery.
United States
