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Enhancing Mass Spectrometry for Biopharmaceutical Product Development

Reputable Mentor II
Reputable Mentor II
Horn D.
Mass spectrometry (MS) has proven to be an indispensable tool for developing complex biotherapeutics such as monoclonal antibodies. The ability to thoroughly characterize proteins facilitates investigation of the functional impact of post-translational modifications, isoform and sequence variations, and protein cleavages. Analytical requirements include determination of intact protein mass, determination of post-translational modification and glycosylation form distribution, detection of minor impurities due to sample processing and handling, and precise localization of modifications. In spite of numerous advances, however, biopharmaceutical researchers continue to face obstacles to the rapid, consistent, and reliable analysis of complex proteins—obstacles such as the need for protein digestion. Learn how intact monoclonal antibody characterization can be accomplished on an LC timescale using a hybrid dual-pressure linear ion trap—high-field Orbitrap™ mass spectrometer. And how the high mass accuracy and high mass resolution provided by Orbitrap technology can help ensure reliable, consistent qualitative and quantitative data. See how advanced protein convolution software enhances biopharmaceutical analysis and provides higher-confidence results. Who should attend: protein therapeutic development scientists, protein characterization scientists, recombinant protein production scientists, and QC/QA scientists
Thermo Fisher Scientific
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Last update:
‎11-09-2021 01:25 AM
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