In residue analysis of environmental and food samples the need exists for the analysis of larger sets of analytes at the same time. Recent developments in scan speed of
triple quadrupole mass spectrometry systems have
fuelled this development, but even more the steadily increasing use of high resolution accurate mass (HRAM) mass spectrometry instrumentation (mainly TOF and
OrbitrapTM based instruments) in residue analysis leads to numerous new options in this field as well into new challenges. One of these challenges is the confirmation
step for the analytes, since precursor ion selected fragmentation comes to its technical limits in terms of the number of analytes and becomes impossible in case of analytes yet unknown or disregarded.