on 06-05-201612:05 PM - edited on 10-15-202111:43 AM by AnalyteGuru
Scheffler K, Damoc E, Bailey A, Josephs J. ASMS 2016 Poster We have successfully implemented the High Mass Range Mode on the Q Exactive Plus and Q Exactive HF mass spectrometers allowing for mass detection up to m/z 8000.
This new operating mode extends the instrument's capabilities to cover all three major workflows for BioPharma characterization.
Desolvation/declustering conditions, ions transfer and trapping have been optimized to allow for improved sensitivity in HMR mode for resolution settings as high as 70K.
Critical parameters for online LC-MS analyses under native conditions are capillary and probe heater temperatures as key factors in supporting desolvation/declustering.