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Enabling Mass Spectrometric Analysis of Intact Proteins in Native Conditions on A Hybrid Quadrupole-Orbitrap Mass Spectrometer

Reputable Mentor II
Reputable Mentor II
Scheffler K, Damoc E, Bailey A, Josephs J.
ASMS 2016 Poster
We have successfully implemented the High Mass Range Mode on the Q Exactive Plus and Q Exactive HF mass spectrometers allowing for mass detection up to m/z 8000. This new operating mode extends the instrument's capabilities to cover all three major workflows for BioPharma characterization. Desolvation/declustering conditions, ions transfer and trapping have been optimized to allow for improved sensitivity in HMR mode for resolution settings as high as 70K. Critical parameters for online LC-MS analyses under native conditions are capillary and probe heater temperatures as key factors in supporting desolvation/declustering.

Thermo Fisher Scientific
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Last update:
‎10-15-2021 11:43 AM
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