Improving analytical throughput is the focus of many
quantitative workflows being developed for early drug
discovery. For drug candidate screening, it is common
practice to use ultra-high performance liquid chromatography
(U-HPLC) coupled with triple quadrupole mass spectrometry.
This approach certainly results in short analytical
run times; however, in assessing the true throughput, all
aspects of the workflow needs to be considered, including
instrument optimization and the necessity to re-run
samples when information is missed.
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