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Development of a Cation-Exchange pH Gradient Separation Platform

Team TFS
Team TFS
MAbs can be highly heterogeneous due to modifications such as sialylation, deamidation and C-terminal lysine truncation. Salt gradient cation exchange chromatography has been used with some success in characterizing MAb charge variants. However, additional effort is often required to tailor the salt gradient method for an individual MAb. In the fast-paced drug development environment, a more generic platform method is desired to accommodate the majority of the MAb analyses.
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Last update:
‎10-16-2013 07:41 AM
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