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Team TFS
Team TFS
A simple, rapid, and sensitive procedure for the determination of gestodene in human plasma by liquid chromatography-tandem mass spectrometry was developed and evaluated. The drug was isolated from a plasma matrix using HyperSep SLE, and the components of the resultant extracts were separated on an Accucore C18 HPLC column under reversed-phase, gradient conditions. Detection was performed on a triple quadrupole mass spectrometer using positive polarity, heated electrospray ionisation (HESI) conditions operating in selected reaction monitoring (SRM) mode. Deuterated gestodene was used as the internal standard. Good chromatographic peak shape and linearity over the dynamic range 0.05 to 5 ng/mL was achieved with excellent precision.
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Last update:
‎10-16-2013 07:41 AM
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