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Reputable Mentor II
Reputable Mentor II
Dauly C, Garcia P, Louette J, Cormant F, Oppermann M, Popot MA, Bonnaire Y, Bailly-Chouriberry L.
ASMS 2012 Poster
Recombinant human erythropoietin (rHuEPO) is a 30-34 kDa glycoprotein banned by racing authorities. To differentiate between horse endogenous EPO and rHuEPOs, methods employing LC-MS/MS or isoelectric focusing (IEF) with double-blotting have been developed. However, the short confirmation-time window of the compound in plasma remains a problem for doping-control laboratories in horse racing. In this study, a new sample preparation technique using disposable anti-EPO monolith columns was combined with nano-LC-MS/MS analysis on a high-resolution Orbitrap mass analyzer. The approach enabled the confirmation and quantification of the rHuEPO target peptides in a single analytical run, with high specificity, sensitivity and resolution.

Thermo Fisher Scientific
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Last update:
‎10-15-2021 09:03 AM
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