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Desorption electrospray ionization using an Orbitrap mass spectrometer: exact mass measurements on drugs and peptides

Reputable Mentor II
Reputable Mentor II
Hu Q, Talaty N, Noll RJ, Cooks RG.
Rapid Commun Mass Spectrom. 2006;20(22):3403-8.
Desorption electrospray ionization (DESI) is implemented on an Orbitrap mass spectrometer. The ion source is described and applications which utilize the high-resolution capabilities of the Orbitrap are emphasized, including the characterization of peptides and active ingredients in pharmaceutical tablets. Measurements are made in less than 1 s at a resolution of 60,000. The implications of the data for the mechanisms of DESI are discussed.
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
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‎11-09-2021 01:47 AM
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