Demonstrating High-Performance Quantitative Analysis of Benzodiazepines using Multiplexed SIM with High-Resolution, Accurate Mass Detection on the Q Exactive LC/MS

[Orbitrap_SciLib]

McHale K.
Application Note 551
The Q Exactive HRAM LC/MS system is a powerful and flexible instrument that can provide both sample identification and quantitative information for forensic toxicology with a single sample analysis. By using the method of multiplexed SIM, eight benzodiazepines in urine were quantified with LLOQs at the pg/mL level and with linear dynamic ranges of 3 to 4 orders of magnitude.


Thermo Fisher Scientific