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Demonstrating High-Performance Quantitative Analysis of Benzodiazepines using Multiplexed SIM with High-Resolution, Accurate Mass Detection on the Q Exactive LC/MS

Reputable Mentor II
Reputable Mentor II
McHale K.
Application Note 551
The Q Exactive HRAM LC/MS system is a powerful and flexible instrument that can provide both sample identification and quantitative information for forensic toxicology with a single sample analysis. By using the method of multiplexed SIM, eight benzodiazepines in urine were quantified with LLOQs at the pg/mL level and with linear dynamic ranges of 3 to 4 orders of magnitude.

Thermo Fisher Scientific
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Last update:
‎10-15-2021 08:37 AM
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