on 05-11-201704:39 AM - edited on 11-09-202104:16 AM by usermigration2
1) Laboratory of Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology (ETH) Zurich, Schmelzbergstrasse 7, CH-8092 Zürich, Switzerland, 2) Institute of Mineralogy, University of Hannover, Callinstrasse 3-9, D-30167 Hannover, Germany International Journal of Mass Spectrometry (2005), V242, pp117–134, doi: 10.1016/j.ijms.2004.12.028 Deciphering the iron isotope message of the human body Thomas Walczyk (1), Friedhelm von Blanckenburg (2) Mass-dependent variations in isotopic composition are known since decades for the light elements such as hydrogen, carbon or oxygen. Multicollector-inductively coupled plasma mass spectrometry (MC-ICP-MS) and double-spike thermal ionization mass spectrometry (TIMS) permit us now to resolve small variations in isotopic composition even for the heavier elements such as iron. Recent studies on the iron isotopic composition of human blood and dietary iron sources have shown that lighter iron isotopes are enriched along the food chain and that each individual bears a certain iron isotopic signature in blood. To make use of this finding in biomedical research, underlying mechanisms of isotope fractionation by the human body need to be understood. In this paper available iron isotope data for biological samples are discussed within the context of isotope fractionation concepts and fundamental aspects of human iron metabolism.