on 06-07-201310:39 AM - edited on 10-15-202112:06 PM by Closed Account
Kil YJ, Tang W, Becker C, Bern M, Kletter D, Imperial J, Olivera B, Morgenstern D, Fenyő D, Ueberheide B. ASMS 2013 Poster Disulfide-rich peptide venoms from animals such as snakes, spiders, scorpions, and certain marine snails represent one of nature's great diversity libraries of bioactive molecules. These neuroactive peptides have stimulated considerable interest as promising candidates for therapeutics as they specifically interact with ion channels and receptors. Predatory marine cone snails of the superfamily Conoidea produce a great variety of neuroactive toxins. The genus Conus (cone snails) in particular have provided a number of pharmaceutical compound leads and drugs for treatment of chronic pain in HIV and cancer patients (Terlau-Olivera, 2004). The largest group within Conoidea, the Turridae, also produces venom, yet their components are largely uncharacterized both structurally and functionally. We explored novel derivitization methods and data analysis strategies for de novo sequencing the cysteine-rich venom components in the unstudied species Unedogemmula bisaya. Companion poster 203 focuses on the chemical derivitization; here we focus on the bioinformatics.