Meyer MR, Helfer AG, Maurer HH.
Bioanalysis. 2014 Aug;6(17):2275-84. doi: 10.4155/bio.14.164.
This paper reviews high-resolution MS approaches published from January 2011 until March 2014 for the quantification of drugs (of abuse) and/or their metabolites in biosamples using LC-MS with time-of-flight or Orbitrap™ mass analyzers. Corresponding approaches are discussed including sample preparation and mass spectral settings. The advantages and limitations of high-resolution MS for drug quantification, as well as the demand for a certain resolution or a specific mass accuracy are also explored.http://www.future-science.com/doi/abs/10.4155/bio.14.164?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acros...