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Current position of high-resolution MS for drug quantification in clinical & forensic toxicology.

Reputable Mentor II
Reputable Mentor II
Meyer MR, Helfer AG, Maurer HH.
Bioanalysis. 2014 Aug;6(17):2275-84. doi: 10.4155/bio.14.164.
This paper reviews high-resolution MS approaches published from January 2011 until March 2014 for the quantification of drugs (of abuse) and/or their metabolites in biosamples using LC-MS with time-of-flight or Orbitrap™ mass analyzers. Corresponding approaches are discussed including sample preparation and mass spectral settings. The advantages and limitations of high-resolution MS for drug quantification, as well as the demand for a certain resolution or a specific mass accuracy are also explored.
Saarland University
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‎10-15-2021 09:25 AM
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