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Considerations for Attaining Improved ETD Performance for Top Down Applications

Reputable Mentor II
Reputable Mentor II
Mullen C, Earley L, Weisbrod C, Syka J, Dunyach J.
ASMS 2015 Poster
Purpose: Increase the per scan signal to noise (S/N) ratio for electron transfer dissociation (ETD) spectra acquired in a Thermo ScientificTMOrbitrapTManalyzer of a hybrid quadrupolemass filter –Orbitrap-quadrupolelinear ion trap (LIT) instrument. Methods: Vary the ETD scan functions by changing the pre-reaction (starting) locations of the precursor and reagent and the order in which they are injected into high pressure cell (HPC) of the dual cell LIT. Results: A three-fold or greater improvement in precursor capacity is realized when the precursor is injected and sequestered into the center section of the HPC.

Thermo Fisher Scientific
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Last update:
‎10-15-2021 12:04 PM
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