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Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping

Reputable Mentor II
Reputable Mentor II
Aaron O. Bailey,1 Stephane Houel,1 Kai Scheffler,2 Eugen Damoc,3 Jennifer Sutton,1 Jonathan L. Josephs
To perform complete characterization of the lysine-linked antibody drug conjugate (ADC) trastuzumab emtansine using both intact mass and peptide mapping approaches with a single benchtop mass spectrometer. Critical quality attribute (CQA) measurements include drug-to-antibody ratio (DAR) and glycosylation pattern via intact mass analysis, and conjugation site localization via peptide mapping.

1 Thermo Fisher Scientific 1 San Jose, CA, USA 2 Dreieich, Germany 3 Bremen, Germany
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Last update:
‎11-09-2021 01:15 AM
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