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Orbitrap_SciLib
Reputable Mentor II
Reputable Mentor II
Aaron O. Bailey,1 Stephane Houel,1 Kai Scheffler,2 Eugen Damoc,3 Jennifer Sutton,1 Jonathan L. Josephs
APPLICATION NOTE 72511
To perform complete characterization of the lysine-linked antibody drug conjugate (ADC) trastuzumab emtansine using both intact mass and peptide mapping approaches with a single benchtop mass spectrometer. Critical quality attribute (CQA) measurements include drug-to-antibody ratio (DAR) and glycosylation pattern via intact mass analysis, and conjugation site localization via peptide mapping.


1 Thermo Fisher Scientific 1 San Jose, CA, USA 2 Dreieich, Germany 3 Bremen, Germany
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Last update:
‎11-09-2021 01:15 AM
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