on 09-20-201902:27 PM - edited on 10-15-202109:53 AM by AnalyteGuru
Angela Criscuolo 1, 2; Tabiwang N. Arrey 2; Eugen Damoc2; Thomas Moehring2; Catharina Crone2 ; Martin Zeller2; Markus Kellmann2 Hupo 2019 Purpose: Structural characterizations of intact monoclonal antibodies by native MS
Methods: Size exclusion chromatography and charge variant chromatography were coupled with a Thermo Scientific™ Orbitrap Exploris™
480 mass spectrometer.
Results: The two methods provided greater depth of analysis of mAbs heterogeneity, showing different benefits respectively.