Angela Criscuolo 1, 2; Tabiwang N. Arrey 2; Eugen Damoc2; Thomas Moehring2; Catharina Crone2 ; Martin Zeller2; Markus Kellmann2
Hupo 2019
Purpose: Structural characterizations of intact monoclonal antibodies by native MS
Methods: Size exclusion chromatography and charge variant chromatography were coupled with a Thermo Scientific™ Orbitrap Exploris™
480 mass spectrometer.
Results: The two methods provided greater depth of analysis of mAbs heterogeneity, showing different benefits respectively.
1 Leipzig University, Leipzig, Germany
2 Thermo Fisher Scientific, Bremen, Germany
United States
